Dr. Mayaki was professor of Public Administration and Management in Niger and Venezuela where he served during the periods 1978-1982 and 1985-1 987. He also worked for ten years in the mining sector in Niger. From the period 2000 to 2004, Dr Mayaki was Visiting Professor at the University of Parix XI where he taught international affairs and international organizations.
He also led researches at the Centre for Research on Europe and the Contemporary World in the same university. In 1996, under the presidency of Ibrahim Bare Ma'inassara, Dr. Mayaki joined the cabinet as Minister in charge for African Integration and Cooperation, before holding the position of Foreign Minister.
He was appointed Prime Minister of the country in November 1997. He remained in charge until January 2000. As Prime Minister of Niger, Dr. Mayaki played a catalyst role in enhancing the social dialogue in the country. He initiated the creation of relevant technical committees in charge of the negotiations with social partners.
In 1998, Dr. Mayaki, with the collaboration of the International Confederation of Free Trade Union, organized a national forum on social dialogue, and lead necessary consultations and measures which resulted in the creation of the first 'National Commission for social dialogue' (Commission Nationale sur le Dialogue Social) in 2000. This commission was the first created in Africa.
In August 2000, he created the Public Policy Analysis Circle (Cercle d'analyse des pol itiques publiques),
a think-tank focusing on health and education policy. In 2004, he became Executive
Director of The Platform supporting rural development stakeholders in Western and Central Africa (The Rural Hub), located in Dakar in Senegal.
Since 2009, Ibrahim Assane Mayaki, is the CEO of the New Partnership for Africa's Development.